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Acyclic nucleoside bisphosphonates: Synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines
- 1.0326296 - ÚOCHB 2010 RIV FR eng J - Journal Article
Doláková, Petra - Dračínský, Martin - Masojídková, Milena - Šolínová, Veronika - Kašička, Václav - Holý, Antonín
Acyclic nucleoside bisphosphonates: Synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines.
European Journal of Medicinal Chemistry. Roč. 44, č. 6 (2009), s. 2408-2424. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT 1M0508
Grant - others:NIH(US) 1UC1AIO62540-01
Institutional research plan: CEZ:AV0Z40550506
Keywords : acyclic nucleoside phosphonates * pyrimidine * bisphosphonates
Subject RIV: CC - Organic Chemistry
Impact factor: 3.269, year: 2009
2-Amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines bearing two equal or different achiral or chiral phosphonoalkoxy chains have been prepared either by aromatic nucleophilic substitution of 2-amino-4,6-dichloropyrimidine or by alkylation of 4,6-dihydroxy-2-(methylsulfanyl)pyrimidine with appropriate phosphonate–bearing building block.
Permanent Link: http://hdl.handle.net/11104/0173438
Number of the records: 1