Future use of mitocans against tumour-initiating cells?

0325050 - ÚMG 2010 RIV DE eng J - Journal Article
Morrison, B.J. - Anděra, Ladislav - Reynolds, B.A. - Ralph, S.J. - Neužil, Jiří
Future use of mitocans against tumour-initiating cells?
Molecular Nutrition & Food Research. Roč. 53, č. 1 (2009), s. 147-153. ISSN 1613-4125. E-ISSN 1613-4133
Institutional research plan: CEZ:AV0Z50520514; CEZ:AV0Z50520701
Keywords : mitocans * tumour-initiating cells * metastasis
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 4.356, year: 2009

Tumour heterogeneity has several important consequences including making their classification by morphological and genetic analysis more difficult because of the diversity of cells, failing to eliminate one of the cell subtypes and differing abilities of the cell subtypes for dissemination and metastasis. Recently, a rare subpopulation of cells within tumours has been described with the ability to initiate and sustain tumour growth, to resist traditional therapies and to allow for secondary tumour dissemination. These cells are termed tumour-initiating cells (TICs). Understanding tumour heterogeneity will be critical for advancing treatments for cancer that target TIC subpopulations of cells in a tumour able to resist traditional treatments and eliminate them before metastatic disease occurs. Therefore, knowledge of the molecular mechanism(s) of resistance of TICs to treatment and overcoming it will be essential in order to develop effective drug strategies for cancer therapy.
Permanent Link: http://hdl.handle.net/11104/0172607