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Two aspartic proteinases secreted by the pathogenic yeast Candida parapsilosis differ in expression pattern and catalytic properties
- 1.0324742 - ÚOCHB 2009 RIV DE eng J - Journal Article
Hrušková-Heidingsfeldová, Olga - Dostál, Jiří - Majer, F. - Havlíková, J. - Hradilek, Martin - Pichová, Iva
Two aspartic proteinases secreted by the pathogenic yeast Candida parapsilosis differ in expression pattern and catalytic properties.
[Dvě aspartátové proteázy sekretované patogenní kvasinkou Candida parapsilosis se liší způsobem exprese i katalytickými vlastnostmi.]
Biological Chemistry. Roč. 390, č. 3 (2009), s. 259-268. ISSN 1431-6730. E-ISSN 1437-4315
R&D Projects: GA ČR GA203/05/0038; GA MŠMT(CZ) LC531
Institutional research plan: CEZ:AV0Z40550506
Keywords : aspartic protease * Candida parapsilosis
Subject RIV: CE - Biochemistry
Impact factor: 2.732, year: 2009
Protease Sapp1p secreted by pathogenic yeast Candida parapsilosis has a higher catalytic activity than the isoenzyme Sapp2p. The gene SAPP2 is transcribed constitutively, while SAPP1 is inducible, it is transcribed only in presence of exogenous protein as a sole source of nitrogen.
Proteáza Sapp1p sekretovaná patogenní kvasinkou Candida parapsilosis má vyšší katalytickou účinnost než isoenzym Sapp2p. Gen SAPP2 je transkribován konstitutivně, zatímco gen SAPP1 je inducibilní a je transkribován jen v přítomnosti exogenní bílkoviny jakožto jediného zdroje dusíku.
Permanent Link: http://hdl.handle.net/11104/0172362
Number of the records: 1