Resorbable polymeric scaffolds for bone tissue engineering: The influence of their microstructure on the growth of human osteoblast-like MG 63 cells

0324229 - FGÚ 2009 RIV US eng J - Journal Article
Pamula, E. - Filová, Elena - Bačáková, Lucie - Lisá, Věra - Adamczyk, D.
Resorbable polymeric scaffolds for bone tissue engineering: The influence of their microstructure on the growth of human osteoblast-like MG 63 cells.
[Resorbovatelné polymerní matrice pro tkáňové inženýrství kostí: vliv mikrostruktury matrice na růst lidských kostních buněk MG 63.]
Journal of Biomedical Materials Research. Part A. 89A, č. 2 (2009), s. 432-443. ISSN 1549-3296. E-ISSN 1552-4965
R&D Projects: GA ČR(CZ) GA106/06/1576; GA AV ČR(CZ) KAN400480701
Institutional research plan: CEZ:AV0Z50110509
Keywords : osteoblast-like MG-63 cells * scaffolds * microstructure
Subject RIV: EI - Biotechnology ; Bionics
Impact factor: 2.816, year: 2009

PLG scaffolds with the same porosity (83%) and an increasing diameter of pores (180-200 µm, 250–320 µm and 400-600 µm) were prepared. The best colonization with cells was observed on the scaffold with the largest pore size. The concentrations of osteopontine and osteocalcine, markers of osteogenic differentiation were the same on all scaffolds

Připravili jsme PLG matrice s velikostí pórů 180-200 µm, 250–320 µm a 400-600 µm s vysokou porozitou (83 %). Nejlepší kolonizace matric kostními buňkami byla pozorována u matric s velikostí pórů 400-600 µm. Koncentrace osteogenních markerů osteopontinu a osteokalcinu byla stejná u všech matric
Permanent Link: http://hdl.handle.net/11104/0171980