Synthesis of novel racemic carbocyclic nucleoside analogues derived from 4,8-dioxatricyclo[4.2.1.0 3,7]nonane-9-methanol and 4-oxatricyclo[4.3.1.0 3,7]decane-10-methanol, compounds with activity against Coxsackie viruses

0324225 - ÚOCHB 2009 RIV CZ eng J - Journal Article
Hřebabecký, Hubert - Dračínský, Martin - De Palma, A. - Neyts, J. - Holý, Antonín
Synthesis of novel racemic carbocyclic nucleoside analogues derived from 4,8-dioxatricyclo[4.2.1.0 3,7]nonane-9-methanol and 4-oxatricyclo[4.3.1.0 3,7]decane-10-methanol, compounds with activity against Coxsackie viruses.
[Syntéza nových racemickýc karbocyklických analog nukleosidů odvozených od 4,8-dioxatricyklo[4.2.1.03,7]nonan-9-methanolu a 4-oxatricyklo[4.3.1.03,7]dekan-10-methanolu, látek s aktivitou proti Coxsackie virům.]
Collection of Czechoslovak Chemical Communications. Roč. 74, č. 3 (2009), s. 469-485. ISSN 0010-0765
R&D Projects: GA MŠMT 1M0508; GA AV ČR 1QS400550501
Institutional research plan: CEZ:AV0Z40550506
Keywords : amines * carbocyclic nucleosides * purines
Subject RIV: CC - Organic Chemistry
Impact factor: 0.856, year: 2009

Novel racemic carbocyclic nucleoside analogues of thymine and 6-substituted purines derived from 4,8-dioxatricyclo-[4.2.1.03,7]nonane-9-methanol and 4-oxatricyclo[4.3.1.03,7]decane- 10-methanol were prepared and tested for the activity against Coxsackie viruses.

Byla syntetizována nová racemická karbocyklická analoga nukleosidů s thyminem a 6-substituovanými puriny odvozená od 4,8-dioxatricyklo-[4.2.1.03,7]nonan-9-methanolu a 4-oxatricyklo[4.3.1.03,7]dekan-10-methanolu a testována na aktivitu proti Coxsackie virům.
Permanent Link: http://hdl.handle.net/11104/0171976