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Synthesis of novel carbocyclic nucleoside analogues derived from 7-oxabicyclo[2.2.1]heptane-2-methanol
- 1.0324204 - ÚOCHB 2009 RIV CZ eng J - Journal Article
Hřebabecký, Hubert - Dračínský, Martin - De Palma, A. - Neyts, J. - Holý, Antonín
Synthesis of novel carbocyclic nucleoside analogues derived from 7-oxabicyclo[2.2.1]heptane-2-methanol.
[Syntéza nových karbocyklických analog nukleosidů odvozených od 7-oxabicyklo[2.2.1]heptan-2-methanolu.]
Collection of Czechoslovak Chemical Communications. Roč. 74, č. 3 (2009), s. 487-502. ISSN 0010-0765
R&D Projects: GA MŠMT 1M0508; GA AV ČR 1QS400550501
Institutional research plan: CEZ:AV0Z40550506
Keywords : carbocyclic nucleosides * purines * thymine
Subject RIV: CC - Organic Chemistry
Impact factor: 0.856, year: 2009
Novel carbocyclic nucleoside analogues of thymine and 6-substituted purines derived from (1R*,2R*,4S*)-7-oxabicyclo[2.2.1]heptane-2-methanol substituted with a base in the position 5-exo or 6-exo were prepared and tested for the activity against Coxsackie viruses.
Byla syntetizována nová karbocyklická analoga nukleosidů s thyminem a 6-substituovanými puriny odvozená od (1R*,2R*,4S*)-7-oxabicyklo[2.2.1heptan-2-methanolu s basí v poloze 5-exo nebo 6-exo a testována na aktivitu proti Coxsackie virům.
Permanent Link: http://hdl.handle.net/11104/0171959
Number of the records: 1