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Membrane cholesterol content influences binding properties of muscarinic M2 receptors and differentially impacts activation of second messenger pathways
- 1.0323633 - FGÚ 2009 RIV NL eng J - Journal Article
Michal, Pavel - Rudajev, Vladimír - El-Fakahany, E. E. - Doležal, Vladimír
Membrane cholesterol content influences binding properties of muscarinic M2 receptors and differentially impacts activation of second messenger pathways.
[Obsah membránového cholesterolu ovlivňuje vazebné vlastnosti muskarinových M2 receptorů a produkci druhých poslů.]
European Journal of Pharmacology. Roč. 606, 1-3 (2009), s. 50-60. ISSN 0014-2999. E-ISSN 1879-0712
R&D Projects: GA ČR(CZ) GA305/05/0452; GA AV ČR(CZ) IAA500110703; GA MŠMT(CZ) LC554
Grant - others:National Institutes of Health(US) NS25743; EC(XE) LipiDiDiet
Institutional research plan: CEZ:AV0Z50110509
Keywords : muscarinic * cholesterol * receptors
Subject RIV: ED - Physiology
Impact factor: 2.585, year: 2009
Cholesterol depletion strongly reduced both potency and efficacy of receptor internalization, decreased efficacy of carbachol in stimulating IP accumulation and the affinity of M2 receptors for N-methylscopolamine. On the other hand increased efficacy of carbachol on cAMP synthesis
Snížení membránového cholesterolu snižuje receptorovou internalizaci, akumulaci IP vyvolanou karbacholem a afinitu M2 receptoru pro N-methylskopolamin. Na druhé straně zvyšuje účinnost karbacholu na syntesu cAMP
Permanent Link: http://hdl.handle.net/11104/0171536
Number of the records: 1