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Astroglia in dementia and Alzheimer´s disease
- 1.0317550 - ÚEM 2010 RIV GB eng J - Journal Article
Rodríguez Arellano, Jose Julio - Olabarria, M. - Chvátal, Alexandr - Verkhratsky, Alexei
Astroglia in dementia and Alzheimer´s disease.
Cell Death and Differentiation. Roč. 16, č. 3 (2009), s. 378-385. ISSN 1350-9047. E-ISSN 1476-5403
R&D Projects: GA ČR GA305/06/1316; GA ČR GA305/06/1464; GA ČR GA309/08/1381; GA MŠMT(CZ) LC554; GA ČR GA305/08/1384
Grant - others:GA MŠk(CZ) 1M0538
Program: 1M
Institutional research plan: CEZ:AV0Z50390512
Keywords : astrocyte * alia-Alzheimer´s disease * dementia
Subject RIV: FH - Neurology
Impact factor: 8.240, year: 2009
Astrocytes, the most numerous cells in the brain, weave the canvas of the grey matter and act as the main element of the homoeostatic system of the brain. We show that in the transgenic model of Alzheimer's disease, reactive hypertrophic astrocytes surround the neuritic plaques, whereas throughout the brain parenchyma astroglial cells undergo atrophy. Astroglial atrophy may account for early changes in synaptic plasticity and cognitive impairments, which develop before gross neurodegenerative alterations.
Permanent Link: http://hdl.handle.net/11104/0167164
Number of the records: 1