Effects of resveratrol pretreatment on tert-butylhydroperoxide induced hepatocyte toxicity in immobilized perifused hepatocytes: Involvement of inducible nitric oxide synthase and hemoxygenase-1

0315839 - ÚEM 2009 RIV NL eng J - Journal Article
Černý, D. - Kutinová-Canová, N. - Martínek, J. - Hořínek, A. - Kmoníčková, Eva - Zídek, Zdeněk - Farghali, H.
Effects of resveratrol pretreatment on tert-butylhydroperoxide induced hepatocyte toxicity in immobilized perifused hepatocytes: Involvement of inducible nitric oxide synthase and hemoxygenase-1.
[Vliv resveratrolu na toxicitu tert-butylhydroperoxidu u imobilizovaných perfundovaných hepatocytů: Úloha inducibilní NO syntasy a hemoxygenasy-1.]
Nitric Oxide-Biology and Chemistry. Roč. 20, č. 1 (2009), s. 1-8. ISSN 1089-8603. E-ISSN 1089-8611
R&D Projects: GA ČR GA305/07/0061; GA MŠMT 1M0508
Grant - others:MZd(CZ) NR9379
Institutional research plan: CEZ:AV0Z50390512
Keywords : Resveratrol * Hepatocyte * Nitric oxide
Subject RIV: FR - Pharmacology ; Medidal Chemistry
Impact factor: 2.506, year: 2009

Resveratrol and silymarin reduce toxic effects induced in rat hepatocytes by tert-butylhydroperoxide. Their protective effects depend on suppression of the inducible nitric oxide synthase (NOS-2) and hemoxygenase-1 (HO-1) gene expression.

Resveratrol a sylimarin snižují totoxické účinky tert-butylhydroperoxidu u potkaních hepatocytů. Mechanismus protektivního účinku spočívá v inhibici genové exprese inducibilní NO syntasy (NOS-2) a hemoxygenasy-1 (HO-1).
Permanent Link: http://hdl.handle.net/11104/0165931