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Ionic liquids and proteases: A clean alliance for semisynthesis

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    0314266 - ÚOCHB 2009 RIV DE eng J - Journal Article
    Wehofsky, N. - Wespe, Ch. - Čeřovský, Václav - Pech, A. - Hoess, E. - Rudolph, R. - Bordusa, F.
    Ionic liquids and proteases: A clean alliance for semisynthesis.
    [Iontové kapaliny a proteazy: Správná kombinace pro semisyntézu.]
    Chembiochem. Roč. 9, č. 9 (2008), s. 1493-1499. ISSN 1439-4227. E-ISSN 1439-7633
    Grant - others:DFG(DE) SPP1191; DFG(DE) SFB610
    Institutional research plan: CEZ:AV0Z40550506
    Keywords : chemoenzymatic synthesis * ionic liquids * peptides * proteases * substrate mimetics
    Subject RIV: CC - Organic Chemistry
    Impact factor: 3.322, year: 2008

    Ionic liquids of the type 1,3-dimethyl-imidazolium dimethylphosphate ([MMIM][Me2PO4]) were used as promising additives to promote the protease-catalyzed ligation of cleavage-sensitive peptide and protein fragments without competing peptide bond cleavages.

    Iontové kapaliny jako1,3-dimethyl-imidazolium dimethylphosphate ([MMIM][Me2PO4]) byly úspěšně použity jako aditivum pro proteasami katalyzovanou ligaci peptidů nebo fragmentů proteinů bez konkurenčního štěpení jejich peptidových vazeb.
    Permanent Link: http://hdl.handle.net/11104/0164834

     
     
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