0309648 - ÚFCH JH 2008 RIV DE eng J - Journal Article
Stasiuk, M. - Bartosiewicz, D. - Gubernator, J. - Cieslik-Boczula, K. - Hof, Martin - Kozubek, A.
A semisynthetic 5-n-alkylresoreinol derivative and its effect upon biomemhrane properties.
[Deriváty semisyntetického 5-n-alkylresoreinolu a jeho biomembránové vlastnosti.]
Zeitschrift fuer Naturforschung. Section C: a Journal of Biosciences. Roč. 62, 11-12 (2007), s. 881-888. ISSN 0939-5075. E-ISSN 1865-7125
R&D Projects: GA AV ČR 1ET400400413
Institutional research plan: CEZ:AV0Z40400503
Keywords : phenolic lipids * hemolytic activity * phospholipase A2 * acetylcholinesterase
Subject RIV: CF - Physical ; Theoretical Chemistry
Impact factor: 0.756, year: 2007

MSAR (1-sulfate-3-myristoyl-5-pentadecylbenzene) is a semisynthetic derivative of 5-n-pentadecylresorcinol (C15:0). MSAR exhibits hemolytic activity against sheep erythrocytes with a EH50 value of (35 +/- 1.7) mu M. At low concentrations MSAR also exhibits the ability to protect cells against their hypoosmotic lysis. This protective effect is significant as, at 0.1 mu M of MSAR, the extent of osmotically induced cell lysis is reduced by approx. 20%. It was demonstrated that the 9-anthroyloxystearic acid signal was most intensively quenched by MSAR molecules, suggesting a relatively deep location of these molecules within the lipid bilayer. MSAR causes an increase of the fluorescence of the membrane potential sensitive probe. This indicates an alteration of the surface charge and a decrease of the local pH value at the membrane surface.

Deriváty semisyntetického 5-n-alkylresoreinolu a jeho biomembránové vlastnosti.
Permanent Link: http://hdl.handle.net/11104/0161718