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Synthesis, cytostatic and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]- and 6-[2-(dialkylamino)vinyl]purine nucleosides
- 1.0305989 - ÚOCHB 2008 RIV GB eng J - Journal Article
Kuchař, Martin - Hocek, Michal - Pohl, Radek - Votruba, Ivan - Shih, I. - Mabery, E. - Mackman, R.
Synthesis, cytostatic and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]- and 6-[2-(dialkylamino)vinyl]purine nucleosides.
[Syntéza, cytostatická a preotivirová aktivita nových 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]- a 6-[2-(dialkylamino)vinyl]purinových nukleosidů.]
Bioorganic & Medicinal Chemistry. Roč. 16, č. 3 (2008), s. 1400-1424. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA MŠMT 1M0508; GA AV ČR 1QS400550501
Institutional research plan: CEZ:AV0Z40550506
Keywords : purines * nucleosides * conjugate additions * cytostatic activity
Subject RIV: CC - Organic Chemistry
Impact factor: 3.075, year: 2008 ; AIS: 0.719, rok: 2008
DOI: https://doi.org/10.1016/j.bmc.2007.10.063
Novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]- and 6-[2-(dialkylamino)vinyl]purine nucleosides were prepared by conjugate additions of nucleophiles to vinyl or ethynylpurines. Cytostatic and antiviral activity of the title compounds is reported.
Nové 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]- a 6-[2-(dialkylamino)vinyl]purinové nukleosidy byly připraveny konjugovanými adecemi nukleofilů na vinyl nebo ethynylpurinu. Článek presentuje i cytostatickou a antivirovou aktivitu těchto sloučenin.
Permanent Link: http://hdl.handle.net/11104/0159107
Number of the records: 1