New 2-alkynyl derivatives of the acyclic nucleoside 9-(2,3-dihydroxypropyl)adenine and their 6-guanidinopurine counterparts as potential effectors of adenosine receptors

0194994 - UOCHB-X 20030302 RIV CZ eng J - Journal Article
Česnek, Michal - Holý, Antonín - Masojídková, Milena
New 2-alkynyl derivatives of the acyclic nucleoside 9-(2,3-dihydroxypropyl)adenine and their 6-guanidinopurine counterparts as potential effectors of adenosine receptors.
Collection of Czechoslovak Chemical Communications. Roč. 68, č. 11 (2003), s. 2201-2218. ISSN 0010-0765
R&D Projects: GA AV ČR IBS4055109; GA MŠMT OC D13.20
Institutional research plan: CEZ:AV0Z4055905
Keywords : adenosine receptors * alkynes * purines
Subject RIV: CC - Organic Chemistry
Impact factor: 1.041, year: 2003

A series of the new 2-alkynyl derivatives of the acyclic nucleoside 9-(2,3-dihydroxypropyl)-adenine and their 6-guanidinopurine analogues were prepared by the Sonogashira coupling. The effect of the prepared compounds on A₁ and A_2A receptors was examined.
Permanent Link: http://hdl.handle.net/11104/0090664