0194857 - UOCHB-X 20030165 RIV IT eng C - Conference Paper (international conference)
Ježek, Jan - Kelkar, Shripad - Vepřek, Pavel - Hajdůch, M. - Sejbal, J. - Trnka, T.
Multiple antigen glycopeptides (MAGs) with Tn tumour antigens and incorporated adjuvant: synthesis and immunobiological activities.
Peptides 2002. Proceedings of the Twenty-Seventh European Peptide Symposium. Napoli: Edizioni Ziino, 2002 - (Benedetti, E.; Pedone, C.), s. 524-525. ISBN 88-900948-1-8.
[Peptides 2002. European Peptide Symposium /27./. Sorrento (IT), 31.08.2002-06.09.2002]
R&D Projects: GA ČR GA303/01/0690
Institutional research plan: CEZ:AV0Z4055905
Keywords : Tn antigen * multiple antigen glycopeptide * synthetic vaccine
Subject RIV: CE - Biochemistry

Multiple antigen glycopeptides (MAGs) containing both tumor antigens of Tn type and incorporated adjuvant norMurNAc-L-Abu-D-iGln were prepared using Fmoc and Dde protection. The obtained MAGs[norMurNAc-L-Abu-D-iGln-L-Lys(X-Y-Y-c-Abu] 2 -Lys-Gly-amide (I,X=Ac, Y=serine Tn; II, X=Ac, Y=threonine Tn; III, X=stearoyl, Y=threonine Tn) are studied for ability to induce humoral immune response.
Permanent Link: http://hdl.handle.net/11104/0090527