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Synthesis of optically active .I.N./I..sup.6./sup.-alkyl derivatives of (R)-3-(adenin-9-yl)-2-hydroxypropanoic acid and related compounds
- 1.0194803 - UOCHB-X 20030109 RIV CZ eng J - Journal Article
Krečmerová, Marcela - Buděšínský, Miloš - Masojídková, Milena - Holý, Antonín
Synthesis of optically active .I.N./I.6-alkyl derivatives of (R)-3-(adenin-9-yl)-2-hydroxypropanoic acid and related compounds.
Collection of Czechoslovak Chemical Communications. Roč. 68, č. 5 (2003), s. 931-950. ISSN 0010-0765
R&D Projects: GA AV ČR IBS4055109; GA MŠMT OC D13.20
Institutional research plan: CEZ:AV0Z4055905
Keywords : adenine * purines * antivirals
Subject RIV: CC - Organic Chemistry
Impact factor: 1.041, year: 2003
Reaction of 6-chloropurine and other nucleobases with (R)-oxiranecarboxylate was studied. Ethyl (R)-3-(6-chloropurin-9-yl)-2-hydroxypropanoate was hydrolyzed to corresponding acid and then treated with various amines to give a series of N 6 -substituted (R)-3-(adenin-9-yl)2-hydroxypropanoic acids.
Permanent Link: http://hdl.handle.net/11104/0090474
Number of the records: 1