0194238 - UOCHB-X 20010345 RIV US eng J - Journal Article
Rejman, Dominik - Snášel, Jan - Liboska, Radek - Točík, Zdeněk - Pačes, Ondřej - Králíková, Šárka - Rinnová, Markéta - Koiš, P. - Rosenberg, Ivan
Oligonucleotides with isopolar phosphonate internucleotide linkage: a new perspective for antisense compounds?
Nucleosides and Nucleotides. Roč. 20, 4/7 (2001), s. 819-823. ISSN 0732-8311
R&D Projects: GA AV ČR IAA4055902; GA MZd NL5441
Institutional research plan: CEZ:AV0Z4055905
Keywords : phosphonate oligonucleotides and RNase H
Subject RIV: CC - Organic Chemistry
Impact factor: 0.798, year: 1999

Several types of isopolar modified oligothymidylates and oligoadenylates (15 mers) with the phosphonate -.I.O-P-CH2_{-O./I.- internucleotide linkage were prepared. The modified oligonucleotides were subjected to the study of their hybridization properties, resistance against nucleases, and the ability to elicit RNase H activity.
Permanent Link: http://hdl.handle.net/11104/0089924}