0194140 - UOCHB-X 20010224 RIV US eng J - Journal Article
Janeba, Zlatko - Holý, Antonín
Synthesis of 8-amino and 8-substituted amino derivatives of acyclic purine nucleoside and nucleotide analogs. Alkylation of 8-substituted purine bases.
Nucleosides Nucleotides & Nucleic Acids. Roč. 20, 4-7 (2001), s. 1103-1106. ISSN 1525-7770. E-ISSN 1532-2335
R&D Projects: GA ČR GV203/96/K001
Institutional research plan: CEZ:AV0Z4055905
Keywords : nucleotide analogs
Subject RIV: CC - Organic Chemistry
Impact factor: 0.508, year: 2001

Two synthetic approaches were used for preparation of 8-amino-, 8-methylamino-, and 8-dimethylaminoadenine and -guanine analogs of PME and HPMP series: (a) direct modification of 8-bromopurine acyclic nucleotide analogs at the 8-position of the base, (b) alkylation of 8-modified purine bases with alkylation agents.
Permanent Link: http://hdl.handle.net/11104/0089830