0193808 - UOCHB-X 20000240 RIV US eng C - Conference Paper (international conference)
Bélec, L. - Slaninová, Jiřina - Lubell, W. D.
Studying the influence of prolyl amide geometry on bioactivity with 5-.I.t./I.-butylproline oxytocin analogs.
Proceedings of the 16th American Peptide Symposium. Peptides for the New Millennium. Boston: Kluwer, 2000 - (Fields, G.; Tam, J.; Barany, G.), s. 630-631. ISBN 0-7923-6445-7.
[Peptides for the New Millennium. American Peptide Symposium /16./. Minneapolis (US), 26.06.1999-01.07.1999]
R&D Projects: GA AV ČR KSK2055603
Institutional research plan: CEZ:AV0Z4055905
Subject RIV: CE - Biochemistry

Three OT analogs were synthesized in which (2S, 5R)-5-tbutylproline was substituted for proline in OT, [Mpa1]-OT (potent agonist) and [dPen1]-OT (potent antagonist). The new analogues were studied using NMR spectroscopy and their biological potency was determined the prolyl amide geometry was correlated with the biological activity.
Permanent Link: http://hdl.handle.net/11104/0089500