0193679 - UOCHB-X 20000029 RIV SIGLE CZ eng C - Conference Paper (international conference)
Koupilová, M. - Patočka, J. - Barth, Tomislav
The Effect of pyroglutamic fragments of vasopressin and oxytocin on the retention of memory after intoxication by neurotoxins QB and DSP-4 in rats.
80-86241-06-8. In: Biologically Active Peptides. Praha: ÚOCHB AVČR, 1999 - (Slaninová, J.; Barth, T.), s. 34-36. Collection Symposium Series., 3.
[Biologically Active Peptides. Conference /6./. Praha (CZ), 21.04.1999-23.04.1999]
R&D Projects: GA ČR GA306/95/0268
Institutional research plan: CEZ:AV0Z4055905
Keywords : T-maze * Y-maze
Subject RIV: CE - Biochemistry

Effects of six analogs of AVP fragment 4-9 on cognitive impairment induced by cholinotoxin 3-quinuclidine benzilate (QB) or by noradrenotoxin (DSP-4) were investigated by means of Y-maze with aversive stimulation and T-maze with appetitive stimulation in Wistar rats. QB and DSP-4 induced a severe learning deficit in pretrained animals. Single preventive administration of the peptides reversed the QB and DSP-4 induced impairment of the retention of memory.
Permanent Link: http://hdl.handle.net/11104/0089374