Structural Studies of anti-CA IX Monoclonal Antibody M75 Fab Fragment in Complex with its Epitope Peptide

0191698 - UMG-J 20033217 RIV SIGLE CZ eng K - Conference Paper (Czech conference)
Mader, Pavel - Štouračová, Renata - Brynda, Jiří - Závada, Jan
Structural Studies of anti-CA IX Monoclonal Antibody M75 Fab Fragment in Complex with its Epitope Peptide.
2004. In: Materials Structure in Chemistry, Biology, Physics and Technology. Czech and Slovak Crystallographic Association, s. 62. ISSN 1211-5894.
[Meeting of the Czech and Slovak structural biologists /3./. Nové hrady (CZ), 11.03.2004-13.03.2004]
R&D Projects: GA ČR GA203/02/0405
Institutional research plan: CEZ:AV0Z5052915
Keywords : CAIX * antibody * structure
Subject RIV: CE - Biochemistry

CA IX is a cell surface protein that exerts capacity of binding cell surface receptors, and is associated with several types of human carcinomas. Monoclonal antibody M75 recognizes specifically an epitope identified as six repeats of amino acid sequence PGEEDLP, localized in the proteoglycan like domain of CA IX. Structural study of the M75 Fab fragment in complex with its epitope peptide PGEEDLPGEEDL is presented.
Permanent Link: http://hdl.handle.net/11104/0087435