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Y chromosome and vimentin used to trace the fate of allogeneic keratinocytes delivered to the wound by the recombined human/pig skin
- 1.0191224 - UMG-J 20010295 RIV CZ eng J - Journal Article
Pokorná, Eva - Brož, L. - Veselý, Pavel - Matoušková, Eva
Y chromosome and vimentin used to trace the fate of allogeneic keratinocytes delivered to the wound by the recombined human/pig skin.
Folia Biologica. Roč. 47, č. 4 (2001), s. 128-134. ISSN 0015-5500. E-ISSN 0015-5500
R&D Projects: GA MZd IZ4368; GA MZd NK6126
Keywords : allogeneic keratinocytes * xenodermis * Y-chromosome FISH
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 0.519, year: 2001
Allogeneic keratinocytes cultured on cell-free pig dermisstimulate wound healing when applied with the epidermal layerfacing the wound. Male keratinocytes were grafted into donorsites of three female patients. Biopsies were taken on days 4, 6 and 9. The Y-chromosome was found (using the fluorescence .I.in situ ./I.hybridization) in donor sites on day 4 and 6, but not on day 9. Conclusion: Allongeneic keratinocytes temporarily "take" to the wound and are replaced by the patient`s cells after about one week.
Permanent Link: http://hdl.handle.net/11104/0086981
Number of the records: 1