Metastatic MHC class I-negative mouse cells derived by transformation with human papillomavirus type 16

0191194 - UMG-J 20010265 RIV GB eng J - Journal Article
Šmahel, M. - Sobotková, E. - Bubeník, Jan - Šímová, Jana - Žák, R. - Ludvíková, V. - Mikyšková, Romana - Kovařík, J. - Jelínek, F. - Povýšil, C. - Marinov, J. - Vonka, V.
Metastatic MHC class I-negative mouse cells derived by transformation with human papillomavirus type 16.
British Journal of Cancer. Roč. 84, č. 3 (2001), s. 374-380. ISSN 0007-0920. E-ISSN 1532-1827
R&D Projects: GA MZd NC5900; GA MZd NC5526; GA ČR GA312/99/0542; GA ČR GA312/98/0826
Institutional research plan: CEZ:AV0Z5052915
Keywords : human papillomavirus * E6/E7 oncogenes * cell transformation
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.942, year: 2001

Mouse cells were transformed with E6/E7 HPV 16 and activatedH-ras oncogenes. An oncogenic cell line, designatedMK16/1/IIIABC, was derived, lacking MHC class I and II molecules on the cell surface and forming metastases in lymph nodes and lungs after prolonged growth of s.c. induced limited protection against challenge with homologous cells. These cells can therefore serve as a model for studying immune reactions against HPV 16-associated tumours.
Permanent Link: http://hdl.handle.net/11104/0086951