Increased expression of fibroblast growth factor receptor 3 in CD34+ BCR-ABL+ cells from patients with chronic myeloid leukemia

0173858 - UEM-P 20043001 RIV GB eng J - Journal Article
Dvořák, Petr - Dvořáková, D. - Doubek, M. - Faitová, Jitka - Pacholíková, J. - Hampl, Aleš - Mayer, J.
Increased expression of fibroblast growth factor receptor 3 in CD34+ BCR-ABL+ cells from patients with chronic myeloid leukemia.
Leukemia. Roč. 17, - (2003), s. 1-8. ISSN 0887-6924. E-ISSN 1476-5551
R&D Projects: GA ČR GA301/03/1122; GA MŠMT LN00A065
Institutional research plan: CEZ:AV0Z5039906; CEZ:MSM 00065269705; CEZ:VZ432100001
Keywords : CD34+cells, imatinib
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 5.116, year: 2003

It was shown that CD34+BCR-ABL+hematopoietic progenitor cells from patients with chronic myeloid leukemia express abnormally highamount of FGFR-3 oncogene. Although increased expression of FGFR-3 was found in majority of late chronic phase patients treated with inerferon alpha or hydroxyurea, the expression was always lowered following treatment with BCR-ABL tyrosine kinase ihibitor STI571. High levels of FGFR-3 were also indentified in CD34+ cells from G-CSF-mobilized blood stem cell harvests from healthy donors, suggesting a potential growth factor-dependent basis for elevated expression of FGFR-3 in CML. These findings have implications for the involvement of FGFR-3 in malignant hematopoiesis.
Permanent Link: http://hdl.handle.net/11104/0070884