0173818 - UEM-P 20033145 RIV US eng J - Journal Article
Smith, S. R. - Bai, F. - Charbonneau, CH. - Janderová, Lenka - Argyropoulos, G.
A promoter genotype and oxidative stress potentially link resistin to human insulin resistance.
Diabetes. Roč. 52, č. 7 (2003), s. 1611-1618. ISSN 0012-1797. E-ISSN 1939-327X
Institutional research plan: CEZ:AV0Z5039906
Keywords : insulin * diabetes
Subject RIV: EA - Cell Biology
Impact factor: 8.298, year: 2003

G/G genotype of a single nucleotide polymorphism (SNP) in the promoter of the human resistin gene, -180C>G, had significantly increased basal promoter activity in adipocytes. A significant interaction was also found between the -180C>G SNP, a marker of oxidative stress (NAD[P]H quinone oxidoreductase mRNA) and homeostasis model assessment of insulin resistance. These data implicate resistin in the pathophysiology of the human insulin resistance syndrome, an effect mediated by the -180C>G promoter SNP and potentially cellular oxidative stress.
Permanent Link: http://hdl.handle.net/11104/0070844