0173760 - UEM-P 20033084 RIV GB eng M - Monography Chapter
Dušek, Zdík - Novotná, Božena - Holejšovská, Iva - Dostál, Miroslav - Vilhelmová, M.
Early and late effects of 1,2-dibromoethane on the hematopoiesis of the chick embryo in ovo.
Human Monitoring for Genetic Effects. Amsterdam: IOS Press, 2003 - (Cebulska-Wasilewska, A.; Au, W.; Šrám, R.), s. 318-328. NATO Sci. Series I., 351
R&D Projects: GA ČR GA304/98/1613
Institutional research plan: CEZ:AV0Z5039906
Keywords : chick embryo * 1,2-dibromoethane * haematopoiesis
Subject RIV: EB - Genetics ; Molecular Biology

Chick embryo in ovo was shown to be a promising system to study the effect of 1,2-dibromoethane (DBE) on haematopoiesis at a developmental stage where the primitive erythroid cells divide and differentiate in circulation. The kinetics of DNA breaks in both erythroid and lymphoid cells implied a genotoxic damage by DBE to the stem cells of the definitive elements and the transmission of this damage through the successive cell generations.
Permanent Link: http://hdl.handle.net/11104/0070786