0173619 - UEM-P 20023074 RIV GB eng J - Journal Article
Politi, V. - Perini, G. - Trazzi, S. - Pliss, Artem - Raška, Ivan - Earnshaw, W. C. - Della Valle, G.
CENP-C binds the alpha-satellite DNA in vivo at specific centromere domains.
Journal of Cell Science. Roč. 115, - (2002), s. 2317-2327. ISSN 0021-9533. E-ISSN 1477-9137
Institutional research plan: CEZ:AV0Z5039906; CEZ:MSM 111100003
Keywords : Alpha-satellite DNA * CENP-C * CENP-B
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 6.954, year: 2002

CENP-C is a fundamental component of the centromere, highly conserved among species and necessary for the proper assembly of the kinetochore structure and for the metaphase-anaphase transition. Our results show that CENP-C can associate with the centromeric DNA sequences in vivo and, together with CENP-B, defines a highly structured organization of the alpha-satellite DNA within the human centromere.
Permanent Link: http://hdl.handle.net/11104/0070648