0173460 - UEM-P 20010056 RIV IE eng J - Journal Article
Koskinen, M. - Vodičková, L. - Vodička, Pavel - Warner, S. C. - Hemminki, K.
Kinetics of formation of specific styrene oxide adducts in double-stranded DNA.
Chemico-Biological Interactions. Roč. 138, č. 2 (2001), s. 111-124. ISSN 0009-2797. E-ISSN 1872-7786
R&D Projects: GA ČR GA313/99/1460
Grant - others:EU(XC) QLK4-1999-01368
Institutional research plan: CEZ:AV0Z5039906
Keywords : biomonitoring * DNA adducts
Subject RIV: EA - Cell Biology
Impact factor: 1.706, year: 2001

In order to compare the intrinsic reactivity of the different nucleophilic sites in DNA towards SO and to evaluate the candidates for human biomonitoring we have determined the second-order tate constants and stabilities of several SC-adducts in double-stranded DNA. These include ?- and ß-isomers of N7-substituted and ?N2-substituted guanines, ?- and ßN3-substituted and ?N6-substituted adenines as well as ßN3-and ?N4-substituted cytosines.
Permanent Link: http://hdl.handle.net/11104/0070493