0172394 - UEB-Q 20033102 RIV NL eng J - Journal Article
Moravcová, Daniela - Kryštof, Vladimír - Havlíček, Libor - Moravec, Jiří - Lenobel, René - Strnad, Miroslav
Pyrazolo[4,3-d]pyrimidines as new generation of cyclin-dependent kinase inhibitors.
Bioorganic and Medicinal Chemistry Letters. Roč. 13, č. 18 (2003), s. 2989ů2992. ISSN 0960-894X. E-ISSN 1464-3405
R&D Projects: GA ČR GA303/02/0875; GA AV ČR KJB4038301
Institutional research plan: CEZ:AV0Z5038910
Keywords : Pyrazolo[4,3-d]pyrimidines * CDK1/cyclin B * anticancer agents
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.182, year: 2003

A search among analogues of anti-CDK purines led to the identification of substituted pyrazolo[4,3-d]pyrimidines as novel inhibitors of CDK1/cyclin B. Some of these derivatives also show antiproliferative activity on cancer cell line K-562, thus may find an application as anticancer agents.
Permanent Link: http://hdl.handle.net/11104/0069433