0172203 - UEB-Q 20013082 RIV DE eng J - Journal Article
Kotala, V. - Uldrijan, S. - Horký, M. - Trbušek, M. - Strnad, Miroslav - Vojtěšek, B.
Potent induction of wild-type p53-dependent transcription in tumour cells by a synthetic inhibitor of cyclin-dependent kinases.
Cellular and Molecular Life Sciences. Roč. 58, č. 9 (2001), s. 1333-1339. ISSN 1420-682X. E-ISSN 1420-9071
R&D Projects: GA ČR GA301/02/0475
Institutional research plan: CEZ:AV0Z5038910
Keywords : Roscovitine * transcriptional activity * tumour cells
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 4.539, year: 2001

Activation of the p53 tumour suppressor protein by distinct forms of stress leads to inhibition of cellular proliferation by inducing cell cycle arrest or apoptosis. The cyclin-dependent kinase inhibitor roscovitine has been shown to induce nuclear accumulation of wild-type p53 in human untransformed and tumour-derived cells. We analyzed the response of different human tumour cell lines to roscovitine treatment with respect to their p53 status.
Permanent Link: http://hdl.handle.net/11104/0069245