0142473 - FGU-C 20030087 RIV NL eng J - Journal Article
Manetto, G. - Silvana Bellini, M. - Deyl, Zdeněk
Application of capillaries with minimized electroosmotic flow to the electrokinetic study of acidic drug-beta-oleoyl-gamma-palmitoyl-L-alpha-phosphatidyl choline liposome interactions.
Journal of Chromatography A. Roč. 990, 1-2 (2003), s. 205-214. ISSN 0021-9673. E-ISSN 1873-3778
Institutional research plan: CEZ:AV0Z5011922
Keywords : liposomes * capillary electrophoresis
Subject RIV: CB - Analytical Chemistry, Separation
Impact factor: 2.922, year: 2003

Interaction of a model set of common drug varying widely in their polarity as well as in their chemical structure with liposomes was investigated by means of capillary electrophoresis. The liposomes showed practically no electrophoretic mobility and formed a stable plug in the capilary. Separation resulted in two regions in the electropherogram, namely that which contained the unbound species and that corresponding to the liposome (lipid)-bound fraction.
Permanent Link: http://hdl.handle.net/11104/0040176