0142454 - FGU-C 20030058 RIV GB eng J - Journal Article
Škárka, Libor - Bardová, Kristina - Brauner, Petr - Flachs, Pavel - Jarkovská, D. - Kopecký, Jan - Ošťádal, Bohuslav
Expression of mitochondrial uncoupling protein 3 and adenine nucleotide translocase 1 genes in developing rat heart: putative involvement in control of mitochondrial membrane potential.
Journal of Molecular and Cellular Cardiology. Roč. 35, č. 3 (2003), s. 321-330. ISSN 0022-2828. E-ISSN 1095-8584
R&D Projects: GA MŠMT LN00A079; GA MŠMT LN00A069; GA ČR GA305/00/1659; GA MZd NE6430
Grant - others:GA UK(CZ) 56/2000; March of Dimes Birth Defects Foundation(US) 6-FY00-331
Institutional research plan: CEZ:AV0Z5011922
Keywords : development * heart * mitochondria
Subject RIV: ED - Physiology
Impact factor: 4.954, year: 2003

Postnatal maturation of the heart depends on the switch from glycolytic to oxidative metabolism and it is associated with decreasing tolerance to oxygen deprivation. We characterized changes in composition and function of cardiac mitochondria during postnatal development in left-ventricular myocardium of male Wistar rats.The results support the view that mitochondrial energy conversion in heart changes during ontogeny and suggest the involvement of UCP3 and/or ANT1 in the control mechanism.
Permanent Link: http://hdl.handle.net/11104/0040157