Effects of mitochondrial KATP modulators on cardioprotection induced by chronic high altitude hypoxia in rats

0142334 - FGU-C 20020057 RIV NL eng J - Journal Article
Neckář, Jan - Szárszoi, Ondrej - Koten, L. - Papoušek, František - Ošťádal, Bohuslav - Grover, G. J. - Kolář, František
Effects of mitochondrial KATP modulators on cardioprotection induced by chronic high altitude hypoxia in rats.
Cardiovascular Research. Roč. 55, č. 3 (2002), s. 567-575. ISSN 0008-6363. E-ISSN 1755-3245
R&D Projects: GA ČR GA306/98/0470; GA ČR GA305/01/0279; GA MŠMT LN00A069
Institutional research plan: CEZ:AV0Z5011922
Keywords : contractile function * hypoxia/anoxia * K-ATP channel
Subject RIV: ED - Physiology
Impact factor: 4.692, year: 2002

Adaptation of rats to chronic hypoxia increases the tolerance of their hearts to acute ischemia/reperfusion injury. Administration of a selective blocker of mitochondrial ATP sensitive potassium channels (KATP) 5-hydroxydecanoate abolished cardioprotective effects of chronic hypoxia; administration of selective KATP channels openers (diazoxide and BMS 191095) induced protection in normoxic hearts and but did not influence hypoxic heart. The results suggest that opening of mitochondrial KATP channels is involved in the cardioprotective mechanism conferred by long-term adaptation to chronic hypoxia.
Permanent Link: http://hdl.handle.net/11104/0040040