Specific spatial learning deficits become severe with age in beta -amyloid precursor protein transgenic mice that harbor diffuse beta -amyloid deposits but do not form plaques

0142235 - FGU-C 20010295 RIV US eng J - Journal Article
Koistinaho, M. - Ort, Michael - Cimadevilla, Jose Maria - Vondrous, R. - Cordell, B. - Koistinaho, J. - Bureš, Jan - Higgins, L.
Specific spatial learning deficits become severe with age in beta -amyloid precursor protein transgenic mice that harbor diffuse beta -amyloid deposits but do not form plaques.
Proceedings of the National Academy of Sciences of the United States of America. Roč. 98, č. 4 (2001), s. 14675-14680. ISSN 0027-8424. E-ISSN 1091-6490
R&D Projects: GA ČR GA309/00/1656
Institutional research plan: CEZ:AV0Z5011922
Keywords : spatial memory * transgenic mice * alzheimer
Subject RIV: FH - Neurology
Impact factor: 10.890, year: 2001

Transgenic mice expressing human beta-amyloid precursor protein were impaired in water maze navigation although they did not form plaques. The impairment increased with age from 3 to 24 months.
Permanent Link: http://hdl.handle.net/11104/0039942