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Mokrá granulace při výrobě léčiv

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    0105033 - UCHP-M 20040287 RIV CZ cze J - Journal Article
    Bělohlav, Z. - Břenková, L. - Durdil, P. - Hanika, Jiří - Řápek, P. - Tomášek, V. - Lehocký, M.
    Mokrá granulace při výrobě léčiv.
    [High-Shear Wet Granulation Process in Drug Production.]
    Chemické listy. Roč. 98, č. 12 (2004), s. 1146-1152. ISSN 0009-2770. E-ISSN 1213-7103
    Institutional research plan: CEZ:AV0Z4072921
    Keywords : granulation * drug * stirred granulators
    Subject RIV: CI - Industrial Chemistry, Chemical Engineering
    Impact factor: 0.348, year: 2004

    Mokrá granulace při výrobě léčiv.

    The authors resume the most important knowledge on the mechanism, course and control of industrial wet granulation of pharmaceuticals in stirred granulators. Measurement of main impeller power input, conditions and consequences of heat transfer in granulation, sensitivity of the process to the shape and size of particles of active substance and transfer of data from a pilot-plant granulator to plant conditions are discussed more in detail. The most reliable method of monitoring the course of wet stirred granulation and for detection of the optimum state of granulated mixture is the measurement of main impeller power input. In addition to the input, also the batch temperature can be monitored which, however, depends more on the total time of stirring than on the actual state of the granulated mixture.The selection of an optimum amount of moisture and, subsequently, also the course of wet granulation are affected by the shape and size of particles of active substances.
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