Number of the records: 1  

Synthesis of (2E)-2-Methyl-3-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)prop-2-enoic acid (VUFB 20609) and 2-Methyl-3-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)propanoic acid (VUFB 20584) as Potential Antileukotrienic Agents

  1. 1.
    0104804 - UCHP-M 20040058 RIV GB eng J - Journal Article
    Jampílek, J. - Doležal, M. - Kuneš, J. - Víchová, P. - Jun, D. - Hanika, Jiří - O´Connor, R. - Clynes, M.
    Synthesis of (2E)-2-Methyl-3-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)prop-2-enoic acid (VUFB 20609) and 2-Methyl-3-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)propanoic acid (VUFB 20584) as Potential Antileukotrienic Agents.
    [Syntéza (2E)-2-methyl-3-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)pr op-2-enové kyseliny (VUFB 20609) and 2-methyl-3-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)propanové kyseliny (VUFB 20584) jakožto potenciálních antileukotrienických látek.]
    Journal of Pharmacy and Pharmacology. Roč. 56, č. 6 (2004), s. 783-794. ISSN 0022-3573. E-ISSN 2042-7158
    Institutional research plan: CEZ:AV0Z4072921
    Keywords : aryl iodides * amarium-diodide * leukotrienes
    Subject RIV: CI - Industrial Chemistry, Chemical Engineering
    Impact factor: 1.348, year: 2004

    The syntheses of (2E)-2-methyl-3-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl) prop-2-enoic acid (VUFB 20609) and racemic 2-methyl-3-(4-{[4-(quinolin-2-ylmethoxy) phenyl]sulfanyl}phenyl)propanoic acid (VUFB 20584) as new potential antileukotrienic drugs are described. Due to a low reactivity of the 4-substituted aryl bromides (coupling of the 4-substituted aryl bromides do not provide an activating functional group with 4-methoxybenzene-1-thiol), special conditions, in particular specific heterogeneous copper catalysts, were used. Catalytic hydrogenation of the conjugated double bond on Pd/C in the presence of the sulfanyl group is discussed. In-vitro cytotoxicity testing was performed using a microplate colorimetric acid phosphatase assay.

    Práce se věnuje syntéze následujících nových látek s potenciálním antileukotrimetickým účinkem: (2E)-2-methyl-3-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl) prop-2-enové kyseliny (VUFB 20609) a racemické 2-methyl-3-(4-{[4-(quinolin-2-ylmethoxy) phenyl]sulfanyl}phenyl)propanové kyseliny (VUFB 20584). Katalytická hydrogenace konjugované dvojné vazby v přítomnosti sulfanylové skupiny na Pd/C katalyzátoru je diskutována.

    Permanent Link: http://hdl.handle.net/11104/0012069

     
     
Number of the records: 1  

  This site uses cookies to make them easier to browse. Learn more about how we use cookies.