Number of the records: 1
SmD1 is required for spliced leader biogenesis
- 1.0104485 - PAU-O 20043063 RIV US eng J - Journal Article
Zeiner, G. M. - Foldynová, Silvie - Sturm, N. R. - Lukeš, Julius - Campbell, D. A.
SmD1 is required for spliced leader biogenesis.
[Protein SmD1 je nezbytný pro biogenezi spliced leader RNA.]
Eukaryotic Cell. Roč. 3, č. 1 (2004), s. 241-244. ISSN 1535-9778
Grant - others:NIH(US) AI34536; NIH(US) AI054496
Institutional research plan: CEZ:AV0Z6022909
Keywords : Kinetoplastida * Trypanosoma * spliced leader RNA
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.954, year: 2004
The Sm-binding site of the kinetoplastid spliced leader RNA has been implicated in accurate spliced leader RNA maturation and trans-splicing competence. In Trypanosoma brucei, RNA interference-mediated knockdown of SmD1 caused defects in spliced leader RNA maturation, displaying aberrant 3'-end formation, partial formation of cap 4, and overaccumulation in the cytoplasm; U28 pseudouridylation was unaffected
Na sekvenci spliced leader RNA se nachází vazebné místo pro Sm proteiny, které je důležité pro správné zrání spliced leader RNA a její účast v tran-splicing procesu. Vypnutí SmD1 genu u Trypanosoma brucei pomocí RNA interference způsobilo změny ve zrání spliced leader RNA. Dochází ke špatné formaci 3´konce, pouze k částečné formaci čepičky 4 a k akumulaci spliced leader RNA v cytoplasmě. U28 pseudouridilace byla nepostižena
Permanent Link: http://hdl.handle.net/11104/0011751
Number of the records: 1