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SmD1 is required for spliced leader biogenesis

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    0104485 - PAU-O 20043063 RIV US eng J - Journal Article
    Zeiner, G. M. - Foldynová, Silvie - Sturm, N. R. - Lukeš, Julius - Campbell, D. A.
    SmD1 is required for spliced leader biogenesis.
    [Protein SmD1 je nezbytný pro biogenezi spliced leader RNA.]
    Eukaryotic Cell. Roč. 3, č. 1 (2004), s. 241-244. ISSN 1535-9778
    Grant - others:NIH(US) AI34536; NIH(US) AI054496
    Institutional research plan: CEZ:AV0Z6022909
    Keywords : Kinetoplastida * Trypanosoma * spliced leader RNA
    Subject RIV: EB - Genetics ; Molecular Biology
    Impact factor: 3.954, year: 2004

    The Sm-binding site of the kinetoplastid spliced leader RNA has been implicated in accurate spliced leader RNA maturation and trans-splicing competence. In Trypanosoma brucei, RNA interference-mediated knockdown of SmD1 caused defects in spliced leader RNA maturation, displaying aberrant 3'-end formation, partial formation of cap 4, and overaccumulation in the cytoplasm; U28 pseudouridylation was unaffected

    Na sekvenci spliced leader RNA se nachází vazebné místo pro Sm proteiny, které je důležité pro správné zrání spliced leader RNA a její účast v tran-splicing procesu. Vypnutí SmD1 genu u Trypanosoma brucei pomocí RNA interference způsobilo změny ve zrání spliced leader RNA. Dochází ke špatné formaci 3´konce, pouze k částečné formaci čepičky 4 a k akumulaci spliced leader RNA v cytoplasmě. U28 pseudouridilace byla nepostižena
    Permanent Link: http://hdl.handle.net/11104/0011751

     
     

Number of the records: 1  

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