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Glycerophosphate-dependent hydrogen peroxide production by rat liver mitochondria
- 1.0103834 - FGU-C 20040081 RIV CZ eng J - Journal Article
Ješina, Pavel - Kholová, D. - Bolehovská, R. - Červinková, Z. - Drahota, Zdeněk - Houštěk, Josef
Glycerophosphate-dependent hydrogen peroxide production by rat liver mitochondria.
[Glycerofosfát-dependentní produkce peroxidu vodíku v jaterních mitochondriích potkana.]
Physiological Research. Roč. 53, č. 3 (2004), s. 305-310. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR GA303/03/0799; GA MŠMT OC 918.50
Institutional research plan: CEZ:AV0Z5011922
Keywords : mitochondrial glycerophosphate dehydrogenace * triiodothyronine * hydrogen peroxide
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
Impact factor: 1.140, year: 2004
We studied the extent to which hormonally-induced mitochondrial glycerophosphate dehydrogenase (mGPDH) activity contributes to the supply of reducing equivalents to the mitochondrial respiratory chain in the rat liver. The activity of glycerophosphate oxidase was compared with those of NADH oxidase and/or succinate oxidase. It was found that triiodothyronine-activated mGPDH represents almost the same capacity for the saturation of the respiratory chain as Complex II. Furthermore, the increase of mGPDH activity induced by triiodothyronine correlated with an increase of capacity for glycerophosphate-dependent hydrogen peroxide production
Hodnotili jsme jakým podílem přispívá mitochondriální glycerofosfát dehydrogenáza (mGPDH) redukčními equivalenty do respiračního řetězce ve srovnání s NADH a succinát oxidázou. Prokázali jsme, že hormonálně stimulovaná glycerofosfát oxidáza mitochondrií jater potkana má stejnou aktivitu jako komplex II. Vzestup aktivity glycerofosfát oxidázy koreloval se zvýšenou kapacitou produkce glycerofosfát dependentní tvorby peroxidů
Permanent Link: http://hdl.handle.net/11104/0011140
Number of the records: 1