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Does Cd36 gene play a key role in disturbed glucose and fatty acid metabolism in Prague hypertensive hypertriglyceridemic rats?

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    0102531 - FGU-C 20040054 RIV CZ eng J - Journal Article
    Kadlecová, Michaela - Čejka, Jakub - Zicha, Josef - Kuneš, Jaroslav
    Does Cd36 gene play a key role in disturbed glucose and fatty acid metabolism in Prague hypertensive hypertriglyceridemic rats?
    [Hraje gen Cd36 klíčovou úlohu při poruchách metabolismu glukózy a mastných kyselin u Pražského hypertenzního hypertriglyceridemického potkana?]
    Physiological Research. Roč. 53, č. 3 (2004), s. 265-271. ISSN 0862-8408. E-ISSN 1802-9973
    R&D Projects: GA ČR GA305/03/0769; GA MŠMT LN00A069
    Institutional research plan: CEZ:AV0Z5011922
    Keywords : hypertension * insulin resistance * metabolic syndrome
    Subject RIV: EB - Genetics ; Molecular Biology
    Impact factor: 1.140, year: 2004

    The polymorphism of Cd36 gene in Prague hypertriglyceridemic (HTG) rat was investigated in order to compare this strain with spontaneously hypertensive rats (SHR). In spite of the fact that HTG and SHR had similar metabolic abnormalities, Cd36 mutation characteristic for SHR was absent in HTG strain. It is evident that genes other than Cd36 play an important role in pathogenesis of metabolic syndrome of HTG rats

    Studovali jsme polymorfismus genu Cd36 u Pražského hypertriglyceridemického potkana (HTG) pro srovnání tohoto kmenu se spontánně hypertenzními potkany (SHR). Navzdory tomu, že HTG a SHR mají podobné metabolické abnormality, mutace Cd36, charakteristická pro SHR, chyběla u HTG kmene. Není pochyb o tom, že důležitou úlohu v patogenezi metabolického syndromu HTG potkanů hrají jiné geny než je CD36
    Permanent Link: http://hdl.handle.net/11104/0009879

     
     

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