0100782 - UOCHB-X 20043007 RIV GB eng J - Journal Article
Hocková, Dana - Holý, Antonín - Masojídková, Milena - Votruba, Ivan
An efficient synthesis of cytostatic mono and bis-alkynylpyrimidine derivatives by the Sonogashira cross-coupling reactions of 2,4-diamino-6-iodopyrimidine and 2-amino-4,6-dichloropyrimidine.
[Výhodná syntéza mono- a bis-alkynylpyrimidinů Sonogashirovou reakcí 2,4-diamino-6-jodpyrimidinu a 2-amino-4,6-dichlorpyrimidinu.]
Tetrahedron. Roč. 60, č. 23 (2004), s. 4983-4987. ISSN 0040-4020. E-ISSN 1464-5416
R&D Projects: GA AV ČR IBS4055109
Grant - others:European Commission(XE) HPAW-2002-90001
Institutional research plan: CEZ:AV0Z4055905
Keywords : pyrimidines * cross-coupling * Sonogashira reaction
Subject RIV: CC - Organic Chemistry
Impact factor: 2.643, year: 2004

A series of 6-alkynyl-2,4-diaminopyrimidine derivatives bearing various substituents at alkynyl moiety was prepared by the Sonogashira cross-coupling reaction of 2,4-diamino-6-iodopyrimidine using Pd(pph3)2Cl2 as catalyst. The same reaction was applied to 2-amino-4,6-dichloropyrimidine. Some of the resulting alkynyl pyrimidines showed considerable cytostatic activity

Byla připravena série 6-alkynyl-2,4-diaminopyrimidinů Sonogashirovou reakcí 2,4-diamino-6-chlorpyrimidinu s Pd(pph3)2Cl2 jako katalysátorem. Některé z látek měly význačný cytostatický účinek
Permanent Link: http://hdl.handle.net/11104/0008271