0100622 - UZFG-Y 20043041 RIV US eng J - Journal Article
Stratil, Antonín - Wagenknecht, Daniel - Van Poucke, M. - Kubíčková, S. - Bartenschlager, H. - Musilová, P. - Rubeš, J. - Geldermann, H. - Peelman, L. J.
Comparative and genetic analysis of the porcine glucocerebrosidase (GBA) gene.
[Komparativní a genetická analýza genu pro glukocerebrosidasu prasete.]
Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology. Roč. 138, - (2004), s. 377-383. ISSN 1096-4959. E-ISSN 1879-1107
R&D Projects: GA ČR GA523/00/0669
Institutional research plan: CEZ:AV0Z5045916
Keywords : acid beta-glucosidase * gene mapping * fluorescence in situ hybridization
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 1.393, year: 2004

The genomic sequence of the porcine (Sus scrofa) glucocerebrosidase (GBA) gene, was determined and compared with human GBA and GBAP. The porcine gene harbours 11 exons and 10 introns, and the genomic organization is identical with human GBA. Three polymorphisms were revealed in the porcine GBA, and the gene was assigned cytogenetically to chromosome 4q21 and was also mapped by linkage analysis and on the RH panel.

Byla stanovena genomická sekvence genu pro glukocerebrosidasu (GBA) prasete a byla porovnána s lidským GBA a GBAP. Gen prasete má 11 exonů a 10 intronů, a genomická organizace je identická s organizací lidského genu. V genu prasete byly odhaleny tři polymorfismy. Gen byl cytogeneticky lokalizován na chromozóm 4q21 a byl rovněž mapován vazbovou analýzou a na RH panelu.
Permanent Link: http://hdl.handle.net/11104/0008119