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Timing of Plk1 and MPF activation during porcine oocyte maturation

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    0100618 - UZFG-Y 20043037 RIV US eng J - Journal Article
    Anger, M. - Klíma, Jiří - Kubelka, Michal - Procházka, Radek - Motlík, Jan - Schultz, R. M.
    Timing of Plk1 and MPF activation during porcine oocyte maturation.
    [Časový průběh aktivace Plk1 a MPF během maturace prasečího oocytu.]
    Molecular Reproduction and Development. Roč. 69, č. 1 (2004), s. 11-16. ISSN 1040-452X. E-ISSN 1098-2795
    R&D Projects: GA AV ČR IBS4050005; GA ČR GA204/03/0816
    Grant - others:FIRCA(US) RO3 TW 05530
    Institutional research plan: CEZ:AV0Z5045916
    Keywords : cell cycle * Mphase promoting factor * meiotic
    Subject RIV: EB - Genetics ; Molecular Biology
    Impact factor: 2.331, year: 2004

    A Polo-like kinase 1 (Plk1) appears to be involved in an autocatalytic loop between CDC25C phosphatase and M phase promoting factor in Xenopus oocytes and leads to activation of MPF that is required for germinal vesicle breakdown.

    Polo-like kináza je pravděpodobně zapojena do autokatalytické smyčky mezi CDC25C fosfatázou a MPF u oocytů Xenopa a vede k aktivaci MPF, která je nutná k rozpadu zárodečného váčku.
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