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Effect of hyaluronidase and PEG chain conjugation on the biologic and antitumour activity of RNase A
- 1.0100592 - UZFG-Y 20043011 RIV US eng J - Journal Article
Matoušek, Josef - Poučková, P. - Hloušková, D. - Zadinová, M. - Souček, J. - Škvor, J.
Effect of hyaluronidase and PEG chain conjugation on the biologic and antitumour activity of RNase A.
[Působení ribonukleasy A konjugované hyaluronidasou a PEG na biologické a protinádorové aktivity.]
Journal of Controlled Release. Roč. 94, - (2004), s. 401-410. ISSN 0168-3659. E-ISSN 1873-4995
R&D Projects: GA ČR GA523/01/0114
Institutional research plan: CEZ:AV0Z5045916
Keywords : antitumour * aspermatogenesis * embryotoxicity
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.297, year: 2004
Subcutaneous application of bovine RNase A conjugated to HYase (bovine hyaluronidase), polyethylene glycol(PEG)and HYase+PEG resulted in a marker reduction of the width of the spermatogenic layers of the mouse testes. The number of sperms in caput epididymidis was significantly desreased in mice injected with conjugated RNase A
Subkutánní aplikace bovinní RNase A kojugované s Hyase (bovidní hyaluronidasa,polyethylen glykolem /PEG) snižoval aspermatogenní efekt. Melanomový nádor rostoucí na athymických myších však byl podstatně zmenšen
Permanent Link: http://hdl.handle.net/11104/0008091
Number of the records: 1