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Membrane Restructuring by Bordetella pertussis Adenylate Cyclase Toxin, a Member of the RTX Toxin Family
- 1.0100389 - MBU-M 20040079 RIV US eng J - Journal Article
Martín, C. - Requero, M. A. - Mašín, Jiří - Konopásek, Ivo - Goni, F. M. - Šebo, Peter - Ostolaza, H.
Membrane Restructuring by Bordetella pertussis Adenylate Cyclase Toxin, a Member of the RTX Toxin Family.
[Restrukturalizace membrán působením člena rodiny RTX toxinů, adenylátcyklasového toxinu Bordetella pertussis.]
Journal of Bacteriology. Roč. 186, č. 12 (2004), s. 3760-3765. ISSN 0021-9193. E-ISSN 1098-5530
R&D Projects: GA AV ČR IAA5020907
Grant - others:GA European Union contract(XX) QLK2-1999-0.0556
Keywords : atc * lipid
Subject RIV: EE - Microbiology, Virology
Impact factor: 4.146, year: 2004
Adenylate cyclase toxin (ACT) of Bordetella pertussis, does not require a protein receptor to bind the membrane bilayer, and this may explain its broad range of host cell types. A varying liposomal bilayer composition leads to significant changes in ACT-induced membrane lysis, measured as efflux of fluorescent vesicle contents.
Ukázali jsme, že inzerce ACT do membrány vede k tvorbě hexagonální fáze a trans-membránového flip-flop přehybu lipidů.
Permanent Link: http://hdl.handle.net/11104/0007891
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