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Dimethyl sulfoxide potentiates death receptor-mediated apoptosis in the human myeloid leukemia U937 cell line through enhancement of mitochondrial membrane depolarization
- 1.0047641 - BFÚ 2007 RIV GB eng J - Journal Article
Vondráček, Jan - Souček, Karel - Sheard, M. A. - Chramostová, Kateřina - Andrysík, Zdeněk - Hofmanová, Jiřina - Kozubík, Alois
Dimethyl sulfoxide potentiates death receptor-mediated apoptosis in the human myeloid leukemia U937 cell line through enhancement of mitochondrial membrane depolarization.
[Dimethylsulfoxid posiluje apoptózu zprostředkovanou receptory smrti v lidské leukemické linii U937 prostřednictvím posílení depolarizace mitochondriální membrány.]
Leukemia Research. Roč. 30, č. 1 (2006), s. 81-89. ISSN 0145-2126. E-ISSN 1873-5835
R&D Projects: GA ČR(CZ) GA524/03/0766
Institutional research plan: CEZ:AV0Z50040507
Keywords : human myeloid leukemia * DMSO * apoptosis
Subject RIV: BO - Biophysics
Impact factor: 2.483, year: 2006
In the present study we described the effects of DMSO on susceptibility of human myeloid leukemia U937 cells towards ligation of distinct death receptors (DRs) were investigated. DMSO sensitized cells towards induction of apoptosis by anti-Fas antibody, tumour necrosis factor-alpha or TNF-related apoptosis-inducing ligand (TRAIL).
V této studii popisujeme účinky DMSO na citlivost lidských buněk myeloidní leukémie U937 vůči aktivaci receptorů buněčné smrti (DR). DMSO zvyšoval citlivost buněk vůči indukci apoptózy prostřednictvím anti-Fas protilátky, TNF-alfa a TRAIL.
Permanent Link: http://hdl.handle.net/11104/0138485
Number of the records: 1