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Synthesis of some N4-substituted derivatives of 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir)
- 1.0029203 - ÚOCHB 2006 RIV CZ eng J - Journal Article
Chalupová, Šárka - Holý, Antonín - Masojídková, Milena
Synthesis of some N4-substituted derivatives of 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir).
[Syntéza některých N4-substituovaných derivátů 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosinu (HPMPC, Cidofovir).]
Collection of Czechoslovak Chemical Communications. Roč. 70, č. 12 (2005), 2053-2065. ISSN 0010-0765
R&D Projects: GA MŠMT(CZ) 1M0508
Grant - others:NIH(US) 1UC1AiO62540-01
Institutional research plan: CEZ:AV0Z40550506
Keywords : HPMPC * ANP * antivirals
Subject RIV: CC - Organic Chemistry
Impact factor: 0.949, year: 2005
1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir) has a broad activity spectrum against DNA viruses. As the systemic drug VireadTM is used for treatment of cytomegalovirus retinitis in AIDS patients. Based on this unique profile of HPMPC we have investigated the effect of the substitution of the amino function at the position 4 upon the antiviral activity.
1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir) je účinný vůči širokému spektru DNA virů. Jako VireadTM se používá pro léčbu cytomegalovirové retinitidy u pacientů s AIDS. Na základě účinků HPMPC byl zkoumán efekt substituce aminofunkce v poloze 4 cytosinové baze na protivirovou aktivitu.
Permanent Link: http://hdl.handle.net/11104/0119069
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