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Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors
- 1.0025458 - ÚOCHB 2006 RIV DE eng J - Journal Article
Caffrey, C. R. - Plachá, L. - Bařinka, Cyril - Hradilek, Martin - Dostál, Jiří - Sajid, M. - McKerrow, J. H. - Majer, P. - Konvalinka, Jan - Vondrášek, Jiří
Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors.
[Homologní modelování a analysa SAR analysis katepsinu D Schistosoma japonicum pomocí statinových inhibitorů ukazuje unikátní sterickou bariéru v aktivním místě důležitou pro návrh inhibitorů.]
Biological Chemistry. Roč. 386, č. 4 (2005), 339-349. ISSN 1431-6730. E-ISSN 1437-4315
R&D Projects: GA MŠMT(CZ) LC512; GA ČR(CZ) GP203/02/P095; GA AV ČR(CZ) IAA400550510
Grant - others:SFSF(US) AI 53247; NATO(XE) CLG 974914
Institutional research plan: CEZ:AV0Z4055905
Keywords : schistotoma * proteases of parasites * modelling
Subject RIV: CE - Biochemistry
Impact factor: 2.577, year: 2005
Aspartic protease from Schistosoma japonicum was prepared, and tested with a panel of specific inhibitors.
Byla pripravena aspartatova proteasa ze Schistosoma japonicum a otestována s panelem specifických inhibitorů.
Permanent Link: http://hdl.handle.net/11104/0115844
Number of the records: 1