0597669 - BTÚ 2025 RIV GB eng J - Journal Article
Walimbwa, S. I. - Malý, Petr - Kafkova, L. R. - Raška, M.
Beyond glycan barriers: non-cognate ligands and protein mimicry approaches to elicit broadly neutralizing antibodies for HIV-1.
Journal of Biomedical Science. Roč. 31, č. 1 (2024), č. článku 83. ISSN 1021-7770. E-ISSN 1423-0127
Institutional support: RVO:86652036
Keywords : HIV-1 vaccine * Glycans * Broadly neutralizing antibodies
OECD category: Pathology
Impact factor: 9, year: 2023 ; AIS: 2.376, rok: 2023
Method of publishing: Open access
Result website:
https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-024-01073-yDOI: https://doi.org/10.1186/s12929-024-01073-y

Human immunodeficiency virus type 1 (HIV-1) vaccine immunogens capable of inducing broadly neutralizing antibodies (bNAbs) remain obscure. HIV-1 evades immune responses through enormous diversity and hides its conserved vulnerable epitopes on the envelope glycoprotein (Env) by displaying an extensive immunodominant glycan shield. In elite HIV-1 viremic controllers, glycan-dependent bNAbs targeting conserved Env epitopes have been isolated and are utilized as vaccine design templates. However, immunological tolerance mechanisms limit the development of these antibodies in the general population. The well characterized bNAbs monoclonal variants frequently exhibit extensive levels of somatic hypermutation, a long third heavy chain complementary determining region, or a short third light chain complementarity determining region, and some exhibit poly-reactivity to autoantigens. This review elaborates on the obstacles to engaging and manipulating the Env glycoprotein as an effective immunogen and describes an alternative reverse vaccinology approach to develop a novel category of bNAb-epitope-derived non-cognate immunogens for HIV-1 vaccine design.
Permanent Link: https://hdl.handle.net/11104/0355783