Nanoscaled porphyrinic metal–organic frameworks: photosensitizer delivery systems for photodynamic therapy

0472473 - ÚACH 2018 RIV GB eng J - Journal Article
Bůžek, Daniel - Zelenka, J. - Ulbrich, P. - Ruml, T. - Křížová, I. - Lang, J. - Kubát, Pavel - Demel, Jan - Kirakci, Kaplan - Lang, Kamil
Nanoscaled porphyrinic metal–organic frameworks: photosensitizer delivery systems for photodynamic therapy.
Journal of Materials Chemistry B. Roč. 5, č. 9 (2017), s. 1815-1821. ISSN 2050-750X. E-ISSN 2050-7518
R&D Projects: GA ČR(CZ) GA16-02098S
Institutional support: RVO:61388980 ; RVO:61388955
Keywords : Cell death * Crystalline materials * Cytotoxicity * Diseases * Nanoparticles
OECD category: Inorganic and nuclear chemistry; Physical chemistry (UFCH-W)
Impact factor: 4.776, year: 2017

The photocytotoxic activity of porphyrin-containing materials including metal–organic frameworks (MOFs) has attracted ever increasing interest. We have developed a simple synthesis of hexagonal PCN-222/MOF-545 nanoparticles, which are powerful in inducing reactive oxygen species-mediated apoptosis of cancer cells upon visible light irradiation. The extent of the cytotoxic effect well correlates with the nanoparticle size and structural instability. High phototoxicity of the presented nanoparticles and their deactivation within several hours open up the door to possible applications in cancer therapy.


Permanent Link: http://hdl.handle.net/11104/0269775


Research data: RSC publishing