0538179 - BFÚ 2021 RIV GB eng J - Journal Article
Remšík, Jan - Pícková, Markéta - Vacek, Ondřej - Fedr, Radek - Binó, Lucia - Hampl, A. - Souček, Karel
TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells.
Scientific Reports. Roč. 10, č. 1 (2020). ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA MZd(CZ) NV17-28518A; GA MZd(CZ) NV18-08-00245; GA ČR(CZ) GA20-22984S
Institutional support: RVO:68081707
Keywords : differentiation * identification * promotes * state
OECD category: Other biological topics
Impact factor: 4.380, year: 2020 ; AIS: 1.285, rok: 2020
Method of publishing: Open access
Result website:
https://doi.org/10.1038/s41598-020-67827-4DOI: https://doi.org/10.1038/s41598-020-67827-4

The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection between cell surface markers and distinct cell phenotypes. We mechanistically dissected the TGF-beta family-driven regulation of Sca-1, one of the most commonly used adult stem cell markers. We further provided evidence that TGF-beta disrupts the lineage commitment and promotes the accumulation of tumor-initiating cells in pre-neoplastic cells.
Permanent Link: http://hdl.handle.net/11104/0316084