Plant viruses as scaffolds for the presentation of vaccine epitopes

0475904 - ÚEB 2018 RIV CZ eng J - Journal Article
Plchová, Helena - Čeřovská, Noemi - Vaculík, Petr - Moravec, Tomáš
Plant viruses as scaffolds for the presentation of vaccine epitopes.
Biologia Plantarum. Roč. 61, č. 1 (2017), s. 1-12. ISSN 0006-3134. E-ISSN 1573-8264
R&D Projects: GA ČR(CZ) GA15-10768S; GA ČR(CZ) GAP501/12/1761
Grant - others:European Regional Development Fund(XE) CZ.2.16/3.1.00/24014
Institutional support: RVO:61389030
Keywords : tobacco-mosaic-virus * x coat protein * human-papillomavirus type-16 * green fluorescent protein * n-terminal segment * triple gene block * cell-to-cell * transient expression * nicotiana-benthamiana * viral vector * transient expression * plant viral expression vectors
OECD category: Virology
Impact factor: 1.424, year: 2017

Within the last two decades, plant viral vectors have emerged as an excellent tool for the expression of foreign peptides and proteins. Virus particles carrying foreign antigenic epitopes present some interesting advantages for vaccine design and other applications. This review covers recent advances in the use of some typical plant viruses with helical particles that present heterologous peptides with particular emphasis on particles derived from the Potato virus X (PVX) and its uses.
Permanent Link: http://hdl.handle.net/11104/0272488